From how large a group of people does God remove sins in Isaiah 5:13-53:12? In what sense is this a universal sacrifice of salvation? In what sense is Jesus' sacrifice wasted on some people?
Isaiah tells us that:
He will sprinkle many nations" (52:15)
"He laid on him the iniquity of us all." (53:6)
"He will justify many" (53:11)
"He bore the sin of many" (53:12)
This is a universal sacrifice of salvation in the sense that Jesus was sacrifice for for the nation, the whole world.
God gives us free will. Isaiah tells us that He was despised and rejected by men, a man of sorrows, and familiar with suffering. Like one from whom men hide their faces he was despised, and we esteemed him not. It is when we do not accept Jesus, the Lamb of God, as Lord and savior of our life.